In 2004, she played Kate Hudson's title character's adolescent niece in Raising Helen.
In 2005, she was the title character's rival in a skating contest in Ice Princess.
In April 2012, she hosted an episode of the new series.
In March 2012, it was announced Panettiere had been cast opposite Connie Britton on the ABC musical drama series Nashville. The pilot reunites Panettiere with Burgess Jenkins (who appears in the first few episodes) from Remember the Titans.
A native of New York, she first appeared in a commercial at the age of 11 months.
She began her acting career by playing Sarah Roberts on One Life to Live (1994–97), and Lizzie Spaulding on Guiding Light (1996–2000), before starring at age 10 as Sheryl Yoast in the Disney feature film Remember the Titans.
The clothing brand Candie's announced that it was premiering an ad campaign for the single in late July.
Thanks to her role on Heroes, she became a regular on the science fiction convention circuit, invited to attend conventions around the world in 2007, including Gen Con, New York Comic Con, and Fan Expo Canada.
Panettiere has complained that her acting options are sometimes limited because "people look at [her] as either the popular cheerleader type or just the blonde".
For her performance in Lifetime Television's 1999 TV movie If You Believe, she was nominated for the Young Artist Award for Young Actress Age Ten or Under in the category of Best Performance in a TV Movie or Pilot.
Panettiere appeared on Fox's Ally Mc Beal as the title character's daughter, played the daughter of a man transitioning to female in HBO Films' Normal, had a recurring guest role on Malcolm in the Middle and guest starred in Law & Order: Special Victims Unit in two different roles.
is an American actress, model, singer, and activist.